Development and Evaluation of a Directly Compressible Co-processed Multifunction Sustained Release Agent for Gliclazide Sustained Release Tablets
نویسندگان
چکیده
Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1: 3 were prepared and evaluated. The DCCSRA exhibited good flow and compressibility. The DCCSRA served as a retardant, binder and lubricant in Gliclazide sustained release tablets. By optimization of DCCSRA quantity in formulation, the drug release pattern of the trial formulation was made similar to the release pattern of the reference product of Gliclazide (GLIZID MR 30).
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